You have accessed back-upped version of our site. Please reffer to new home page for a more up-to-date information.
Virtual screening services
Quantum is a leading company providing drug screening services in-silico and, thus, delivering to it clients strong inhibitors against variety of target-proteins
We apply our proprietary developed computational technology QUANTUM, which shows outstanding accuracy in forecasting binding affinities. The hit rate of the QUANTUM performance is about 50%, it means that a half of found in silico strong inhibitors would be confirmed in in-vitro testing!!!
Click here to download a brochure about QUANTUM hit Identification technology.
|
|
Title: Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli |
|
 |
Functional Class: Transferase Primary citation: Kim, P.,Zhang, Y.M.,Shenoy, G.,Nguyen, Q.A.,Boshoff, H.I.,Manjunatha, U.H.,Goodwin, M.B.,Lonsdale, J.,Price, A.C.,Miller, D.J.,Duncan, K.,White, S.W.,Rock, C.O.,Barry III, C.E.,Dowd, C.S. Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem. v49 pp.159-171, 2006 |
Abstract Title: Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli.
Keywords: Dimethylthiophen-2(5h)-one, 3-oxoacyl-[acyl-carrier-protein], (5r)-5-[(1e)-buta-1,3-dienyl]-4-hydroxy-3,5-, (2aqb:a,, Coli, Synthase, Escherichia, Bacteria, Focused compound library, Targeted chemical collection, Pre-selected, Prescreened, Measurement, Estimation, Prediction, Hts, Uhts, High throughput screening, Ultra high-throughput screening, Development, Profiling, Hit, Lead, Hits, Leads, Drug candidate, Chemicals, Entity, Therapeutic agents, Small molecules, In vitro, Novel active compounds, Focused compound library, Targeted hit library, Entities collection, In-vitro, Vendors, Providers, Distributors, Cro, Medicinal chemists, Diverse range, Structurally diverse building blocks, Hit rich collection, Synthesized, Develop new focused arrays, Privileged scaffolds profile, Profiling, Pre-screened, Methods and principles in medicinal chemistry, Synthetic organic, Computational chemistry, Subset of, Broad variety of organic compounds, Diversity analysis, Synthetic tractability and drug like properties, Computer-aided, Optimization,
