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Virtual screening services
Quantum is a leading company providing drug screening services in-silico and, thus, delivering to it clients strong inhibitors against variety of target-proteins
We apply our proprietary developed computational technology QUANTUM, which shows outstanding accuracy in forecasting binding affinities. The hit rate of the QUANTUM performance is about 50%, it means that a half of found in silico strong inhibitors would be confirmed in in-vitro testing!!!
Click here to download a brochure about QUANTUM hit Identification technology.
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Title: CELLOBIOHYDROLASE CEL7A WITH LOOP DELETION 245-252 AND BOUND NON-HYDROLYSABLE CELLOTETRAOSE |
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Functional Class: Hydrolase Primary citation: von Ossowski, I.,Stahlberg, J.,Koivula, A.,Piens, K.,Becker, D.,Boer, H.,Harle, R.,Harris, M.,Divne, C.,Mahdi, S.,Zhao, Y.,Driguez, H.,Claeyssens, M.,Sinnott, M.L.,Teeri, T.T. Engineering the exo-loop of Trichoderma reesei cellobiohydrolase, Cel7A. A comparison with Phanerochaete chrysosporium Cel7D J.Mol.Biol. v333 pp.817-829, 2003 |
Abstract Title: Engineering the exo-loop of Trichoderma reesei cellobiohydrolase, Cel7A. A comparison with Phanerochaete chrysosporium Cel7D.
Keywords: O1-methyl-glucose, Research, Molecular, Sandwich, Catalytic, Glycosyl, (1q2e:null), Non-u.s., D1q2eb_, Trichoderma, Binding, Protein, Proteins, (1q2e:a,, Compounds, Secondary, Cellulose, 1q2eb0, Exocellobiohydrolase, Core, (2-mer), Study, Sugar, Glucose, Hydrolyzing, Chain, (cellulase,, 1q2ea0, Stability, Cbh1), Gov't, Concanavalin, Alignment, Amino, Synthetic, Family, Support, Mutation, Activity,, Acid, Models, Construct, 4-beta-cellobiosidase, Fungus, Beta, Reesei,, Phanerochaete, O-glycosyl, Data, Mainly, Metabolism, Engineering, 1,4-beta-d-glucan, Distorted, Comparative, Crystallography, Tertiary, N-acetyl-d-glucosamine, Sites, Hydrolase, Carbohydrate, Calcium, Enzyme, D1q2ea_, Subunit, Structure, Reesei, A-like, Denaturation, Beta, Cellobiohydrolase, Pyroglutamic, Lectins/glucanases, Sequence, Cel7a, 4-deoxy-4-thio-beta-d-glucopyranose, X-ray, Endoglucanase, Acid, Focused compound library, Targeted chemical collection, Pre-selected, Prescreened, Measurement, Estimation, Prediction, Hts, Uhts, High throughput screening, Ultra high-throughput screening, Development, Profiling, Hit, Lead, Hits, Leads, Drug candidate, Chemicals, Entity, Therapeutic agents, Small molecules, In vitro, Novel active compounds, Focused compound library, Targeted hit library, Entities collection, In-vitro, Vendors, Providers, Distributors, Cro, Medicinal chemists, Diverse range, Structurally diverse building blocks, Hit rich collection, Synthesized, Develop new focused arrays, Privileged scaffolds profile, Profiling, Pre-screened, Methods and principles in medicinal chemistry, Synthetic organic, Computational chemistry, Subset of, Broad variety of organic compounds, Diversity analysis, Synthetic tractability and drug like properties, Computer-aided, Optimization,
