You have accessed back-upped version of our site. Please reffer to new home page for a more up-to-date information.
Virtual screening services
Quantum is a leading company providing drug screening services in-silico and, thus, delivering to it clients strong inhibitors against variety of target-proteins
We apply our proprietary developed computational technology QUANTUM, which shows outstanding accuracy in forecasting binding affinities. The hit rate of the QUANTUM performance is about 50%, it means that a half of found in silico strong inhibitors would be confirmed in in-vitro testing!!!
Click here to download a brochure about QUANTUM hit Identification technology.
|
|
Title: Crystal structure of HNF4a LBD in complex with the ligand and the coactivator SRC-1 peptide |
|
 |
Functional Class: Transcription Primary citation: Duda, K.,Chi, Y.-I.,Shoelson, S. Structural Basis for HNF-4alpha Activation by Ligand and Coactivator Binding J.Biol.Chem. v279 pp.23311-23316, 2004 |
Abstract Title: Structural basis for HNF-4alpha activation by ligand and coactivator binding.
Keywords: Synthetic, Coactivator-1, Domain, Mainly, Factors, Nuclear, Support, Binding, Sites, (1pzl:b), Research, Hepatocyte, Dna-binding, Myristic, Construct, Alpha, Coactivator, Dna-dependent, (homo, Acid, Molecular, Relationship, Orthogonal, Models, Nuclear, Retinoid, Conformation, Bundle, Regulation, Sapiens), Src-1, Factor, Alpha, Humans, Ligands, Structure, Sapiens, Hormone, Structure-activity, Phosphoproteins, Proteins, U.s., Activity, 1pzla0, Transcription,, Peptides, (1pzl:a), Nucleus, P.h.s., Non-u.s., Steroid, Transcription, Ligand-binding, Binding, Ligand-dependent, 4-alpha, Homo, Receptor, D1pzla_, Human, Transcription, Proteins, Receptor, Protein, D1pzlb_, Gov't, Tertiary, Chemicals, Cheminformatics, Chemistry projects, Collaborative services, Collection, Collections, Combichem, Combinatorial chemistry, , Combinatorial services, Compound collections, Compound design, Compound libraries, Compound sets, Compound synthesis, Compound screening, Compounds, Computational design, Contract research organisation, Custom screening, Customised libraries, Database, Discovery, Diverse, Diverse compound collections, Diverse screening libraries, Diversity, Drug design, Drug development, Gene protein coupled receptors, Hit-to-lead, Hit generation, Htos, Hts, I nformatics, Ion channels, Lead discovery, Lead generation, Lead profiling, Lead optimisation, Libraries of chemical compounds, Medicinal chemistry, Molecular, Molecular diversity, Molecular diversity screening, Molecular formula, Molecular informatics, Molecular screening, Molecule, Organic,
