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Virtual screening services

Quantum is a leading company providing drug screening services in-silico and, thus, delivering to it clients strong inhibitors against variety of target-proteins

We apply our proprietary developed computational technology QUANTUM, which shows outstanding accuracy in forecasting binding affinities. The hit rate of the QUANTUM performance is about 50%, it means that a half of found in silico strong inhibitors would be confirmed in in-vitro testing!!!

Click here to download a brochure about QUANTUM hit Identification technology.

PDB ID: 1NNE
Title: Crystal Structure of the MutS-ADPBeF3-DNA complex
	Functional Class: DNA Binding Protein/dna Primary citation: Alani, E.,Lee, J.Y.,Schofield, M.J.,Kijas, A.W.,Hsieh, P.,Yang, W. Crystal structure and biochemical analysis of the MutS-ADP-Beryllium Fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair J.Biol.Chem. v278 pp.16088-16094, 2003

Abstract Title: Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair.

Keywords: Thermus, Fluorides, Mismatch, Research, H-like, Muts,, Coli, Triphosphate, Base, Muts, Adenosine, Dna-binding, Cerevisiae, Beryllium, Fungal, Proteins, Domain, Triphosphate, D1nneb3, D1nneb2, D1nneb1, D1nneb4, Nucleoside, Escherichia, U.s., Proteins, Aquaticus, (1nne:a,, 5'-d(p*gp*gp*ap*cp*gp*ap*gp*cp*cp*gp*cp*cp*gp*cp*tp*ap*gp*cp*gp*tp*cp*g)-, Saccharomyces, Diphosphate, Synthetic, Repair, (a/b), Support, Sulfate, Transporter, Adenosinetriphosphatase, Hydrolases, Beryllium, (a+b), Construct, Pair, 5'-d(*gp*cp*gp*ap*cp*gp*cp*tp*ap*gp*cp*gp*tp*gp*cp*gp*gp*cp*tp*cp*gp*tp*c)-, Trifluoride, Metabolism, N-terminal, Mismatch, Ribonuclease, 1,2-ethanediol, Atpase, Domain-like, Repair, D1nnea2, D1nnea3, D1nnea1, D1nnea4, Bacterial, Crystallography, Motif, Binding, Protein, (1nne:c), Adenosine-5'-diphosphate, Damaged, P-loop, Alpha, Containing, Beta, Carrier, Alpha, (1nne:d), Gov't, C-terminal, P.h.s., Bacteria, Organic chemistry, Organic compounds, Organic molecule collections, Outsourcing, Pass drug screening, Pharma, Pharmaceuticals, Pharmacology, Pharmacophore, Protease, Qsar, Receptor, Robotic automation, Sar, Samples, Screening, Screening libraries, Screening samples, Structure-based design, Potency, Synthetic feasibility, Supplier, Synthesis, Synthetic, Target analysis, Targeted screening, Pre-existing libraries, Target specific criteria, Targeted selection of compounds, Provide the lead series for synthesis and biological testing, Inhibitor chemotypes, Natural combinatorial chemistry, Ncc, Array, Assay, Focused combinatorial libraries, Compounds for high throughput screening, High throughput screening, Combichem, Combinatorial, Combinatorial screening, Combinatorial screening libraries, Compound collection, Compound library, Compounds collection, Lead discovery, Libraries, Library, Mdl compatible database, Molecular diversity screening,