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Virtual screening services
Quantum is a leading company providing drug screening services in-silico and, thus, delivering to it clients strong inhibitors against variety of target-proteins
We apply our proprietary developed computational technology QUANTUM, which shows outstanding accuracy in forecasting binding affinities. The hit rate of the QUANTUM performance is about 50%, it means that a half of found in silico strong inhibitors would be confirmed in in-vitro testing!!!
Click here to download a brochure about QUANTUM hit Identification technology.
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Title: 1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN |
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Functional Class: Complex (hormone/receptor) Primary citation: Sundstrom, M.,Lundqvist, T.,Rodin, J.,Giebel, L.B.,Milligan, D.,Norstedt, G. Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J.Biol.Chem. v271 pp.32197-32203, 1996 |
Abstract Title: Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.
Keywords: Growth, 4-helical, Somatotropin, Immunoglobulin-like, Proteins, Humans, Receptors, Hematopoietin/interferon-class, Up-down, Receptor, D1hwgc1, Cytokine, (homo, Molecular, Cytokines, 1hwgc2, Hormone, 1hwgb2, Somatotropin, Models, Hormone, 1hwga0, D1hwgc2, Bundle, Beta, Homo, Sapiens), Membrane, Beta-sandwich, Protein, Recombinant, Type, Extracellular, Sapiens, Data, Hormone, Cytokine, D1hwga_, 1hwgc1, Proteins, Binding, Beta, Sandwich, Chain:, Alpha, Alpha, (1hwg:b,, Hormone;, 1hwgb1, (1hwg:a), Antagonists, Sequence, Hormone,, Region, Mainly, D1hwgb1, D1hwgb2, Bonding, Fibronectin, Growth, Long-chain, Human, Activity, Crystallography, Hydrogen, (d200-domain), X-ray, Organic chemistry, Organic compounds, Organic molecule collections, Outsourcing, Pass drug screening, Pharma, Pharmaceuticals, Pharmacology, Pharmacophore, Protease, Qsar, Receptor, Robotic automation, Sar, Samples, Screening, Screening libraries, Screening samples, Structure-based design, Potency, Synthetic feasibility, Supplier, Synthesis, Synthetic, Target analysis, Targeted screening, Pre-existing libraries, Target specific criteria, Targeted selection of compounds, Provide the lead series for synthesis and biological testing, Inhibitor chemotypes, Natural combinatorial chemistry, Ncc, Array, Assay, Focused combinatorial libraries, Compounds for high throughput screening, High throughput screening, Combichem, Combinatorial, Combinatorial screening, Combinatorial screening libraries, Compound collection, Compound library, Compounds collection, Lead discovery, Libraries, Library, Mdl compatible database, Molecular diversity screening,
