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Virtual screening services
Quantum is a leading company providing drug screening services in-silico and, thus, delivering to it clients strong inhibitors against variety of target-proteins
We apply our proprietary developed computational technology QUANTUM, which shows outstanding accuracy in forecasting binding affinities. The hit rate of the QUANTUM performance is about 50%, it means that a half of found in silico strong inhibitors would be confirmed in in-vitro testing!!!
Click here to download a brochure about QUANTUM hit Identification technology.
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Title: STRUCTURE OF AN ARCHEAL HOMOLOG OF THE EUKARYOTIC RNA POLYMERASE II RPB4/RPB7 COMPLEX |
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Functional Class: Transferase Primary citation: Todone, F.,Brick, P.,Werner, F.,Weinzierl, R.O.,Onesti, S. Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex. Mol.Cell v8 pp.1137-1143, 2001 |
Abstract Title: Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex.
Keywords: Rbp7, Research, Non-u.s., Motifs, Archaeon, Molecular, Dna-directed, Jannaschii, Dimerization, Acetyltransferase,, Polymerase, (rpof), Dna-binding, 1go3e1, Methanococcus, Rbp4, (1go3:e,, D1go3e2, Barrel, D1go3e1, Dna-directed, D1go3m2, Polymerase;, D1go3m1, Shock, Proteins, 1go3m1, Nucleic, (rpoe), Archaeal, Activity, Protein, Helix, Hairpins, Domain, Binding, Nucleic, Fold, (1go3:f,, Subunit, Heterodimerisation, Proteins, Quaternary, (dihydrolipoamide, Nucleus, Gov't, X-ray, Amino, Support, Subunit-like, Hrdc-like, E2p), Models, (a+b), Bundle, Beta, Dodecin, Data, Polymerase, Acid-binding, Domain-like, Transferase, Mainly, Cold, Crystallography, Tertiary, Binding, 1go3f2, 1go3f1, Acid, 1go3n2, N-terminal,, Orthogonal, Transcription, Subunits, Ob-fold, Alpha, Subunit, Structure, Polymerase, Beta, D1go3n_, Alpha, Sequence, 1go3n1, Humans, C-terminal, Alignment, Acid, D1go3f_, Focused compound library, Targeted chemical collection, Pre-selected, Prescreened, Measurement, Estimation, Prediction, Hts, Uhts, High throughput screening, Ultra high-throughput screening, Development, Profiling, Hit, Lead, Hits, Leads, Drug candidate, Chemicals, Entity, Therapeutic agents, Small molecules, In vitro, Novel active compounds, Focused compound library, Targeted hit library, Entities collection, In-vitro, Vendors, Providers, Distributors, Cro, Medicinal chemists, Diverse range, Structurally diverse building blocks, Hit rich collection, Synthesized, Develop new focused arrays, Privileged scaffolds profile, Profiling, Pre-screened, Methods and principles in medicinal chemistry, Synthetic organic, Computational chemistry, Subset of, Broad variety of organic compounds, Diversity analysis, Synthetic tractability and drug like properties, Computer-aided, Optimization,
