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Virtual screening services
Quantum is a leading company providing drug screening services in-silico and, thus, delivering to it clients strong inhibitors against variety of target-proteins
We apply our proprietary developed computational technology QUANTUM, which shows outstanding accuracy in forecasting binding affinities. The hit rate of the QUANTUM performance is about 50%, it means that a half of found in silico strong inhibitors would be confirmed in in-vitro testing!!!
Click here to download a brochure about QUANTUM hit Identification technology.
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Title: THE 1.7 ANGSTROM STRUCTURE OF WILD TYPE DISULFIDE BOND FORMATION PROTEIN (DSBA) |
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Functional Class: Disulfide Oxidoreductase Primary citation: Guddat, L.W.,Bardwell, J.C.,Glockshuber, R.,Huber-Wunderlich, M.,Zander, T.,Martin, J.L. Structural analysis of three His32 mutants of DsbA: support for an electrostatic role of His32 in DsbA stability. Protein Sci. v6 pp.1893-1900, 1997 |
Abstract Title: Structural analysis of three His32 mutants of DsbA: support for an electrostatic role of His32 in DsbA stability.
Keywords: Hydrogen-ion, 3-layer(aba), (dsba), (a/b), Proteins, Support, Sites, Research, (1fvk:a,, D1fvkb_, Coli, Molecular, 1fvkb0, Stability, Disulfide-bond, Models, Sandwich, Conformation, Dsba-like, Beta, Crystallization, Alpha, Protein, Escherichia, Histidine, Bond, Facilitator, Electrochemistry, Thioredoxin-like, Beta, Disulfide-isomerase, Formation, Drug, Disulfide, Concentration, D1fvka_, X-ray, 1fvka0, Fold, Non-u.s., Binding, Glutaredoxin, Formation, Thioredoxin, Thermodynamics, Protein, Crystallography, Gov't, Oxidation-reduction, Focused compound library, Targeted chemical collection, Pre-selected, Prescreened, Measurement, Estimation, Prediction, Hts, Uhts, High throughput screening, Ultra high-throughput screening, Development, Profiling, Hit, Lead, Hits, Leads, Drug candidate, Chemicals, Entity, Therapeutic agents, Small molecules, In vitro, Novel active compounds, Focused compound library, Targeted hit library, Entities collection, In-vitro, Vendors, Providers, Distributors, Cro, Medicinal chemists, Diverse range, Structurally diverse building blocks, Hit rich collection, Synthesized, Develop new focused arrays, Privileged scaffolds profile, Profiling, Pre-screened, Methods and principles in medicinal chemistry, Synthetic organic, Computational chemistry, Subset of, Broad variety of organic compounds, Diversity analysis, Synthetic tractability and drug like properties, Computer-aided, Optimization,
