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Quantum Drug hit identification tool
Drug Hit Identification Tool calculates the IC50 (Kd, Ki, pKd) value of any protein-ligand complex, docks a small-molecule in the active site of a protein and performs screening a library of compounds against a target-protein or DNA/RNA. Hit Identification Tool consists of three modules: The IC50 module, 2) Ligand Docking and 3) Library Screening modules. Drug Hit Identification Tool can run both in Windows and Linux environments.
Hit Identification overview brochure
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Title: A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES |
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Functional Class: Cytokine Primary citation: Kim, Y.,Shin, J.,Li, R.,Cheong, C.,Kim, K.,Kim, S. A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases. J.Biol.Chem. v275 pp.27062-27068, 2000 |
Abstract Title: A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases.
Keywords: Homology, Emap, Domain, Proteins, Support, Binding, Sites, Conformation, Nucleic, Fold, 1euja0, Neoplasm, E2p), (homo, Molecular, Activating, Endothelial, Acid, Acetyltransferase,, Models, Synthetases, Beta, Binding, Ob-fold, Sapiens), Acyl-trna, Rna-binding, Sapiens, D1euja_, Polypeptide, Humans, Proteins, Monocyte, Beta, Acid-binding, Non-u.s., D1eujb_, Barrel, 1eujb0, (1euj:a,, Antineoplastic, Research, Sequence, Data, Mainly, Nucleic, Homo, Agents, Cytokines, Human, Trna, Protein, Acid, Gov't, (dihydrolipoamide, Amino, Desriptors, Training set, In silico, Studies, Development, Assessment, Scoring function, Low-frequency normal modes, Degrees of freedom, Geometry refinement (optimization), Investigation, Computation of lowest-frequency modes of, Binding energy prediction, Conformational flexibility, Pharmacophore, Three-dimensional quantitative structure activity relationship methods, Conformational analysis, Profiling, ,
